Salvicatone A
The authors identified the structure of Salvicatone A in two stages, the second step being the use of Structure Elucidator Suite to validate the proposed structure.
The History of Chemical Nomenclature and ACD/Name
Chemical nomenclature may seem like a simplistic chemistry discipline; a requirement of every chemical pursuit that is often overlooked for the vital importance it plays. Here we discuss the legacy of our contribution to the field of chemical nomenclature - ACD/Name - and take a look at what has changed in the field of chemical naming over the past three decades.
NMR Acronyms Decoded
Understand the acronyms and abbreviations of the field of NMR. Explore general and experiment-specific acronyms in this essential guide.
Implement ICH Q14 Guidelines More Easily with Method Development Software
Method development software, AutoChrom®, can help implement elements of the ICH Q14 guidelines. AutoChrom streamlines method development and helps you create robust methods faster. Tools and features within the software align with specific elements of the analytical procedure lifecycle.
Pseudochelin A
Sonnenschein et al. investigated the fungus Pseudoalteromonas piscicida S2040 to yield pseudochelin A - a new siderophore containing a 4,5-dihydroimidazole moiety. This challenging structure containing eight heteroatoms (three atoms of nitrogen and fife atoms of oxygen) was elucidated by Structure Elucidator fully automatically in 1.5 seconds.
2023 in Review: Was it a Year of AI?
President and CEO, Daria Thorp, reflects on the past year and how the emerging technology of Generative AI and Machine Learning (ML) application in drug discovery and development has inspired companies to look for further industrial applications.
The Curse of Dead Data in Analytical Chemistry
This Halloween, we will explore how data “dies” and why you can’t bring it back to life. Not only that, but we will discover the secret of how you can keep your analytical data alive… forever!
Nordine
Sesquiterpenoids are a class of compounds known to have complex structures, and due to the wide variability of these compounds, it is often challenging to determine the exact structure. Here we discuss the incorrect determination of the structure of Nordine, and later correction; as well as the elucidation of the correct structure using CASE.
How AstraZeneca is Managing their Extractables and Leachables Data
Getting Control of Extractables and Leachables Data Many medicines come in a container, whether a bottle, blister pack, syringe, or inhaler. We rarely think about these container-closure systems, but what if they adversely interacted with our medicines or slowly released a toxic contaminant? Extractables and leachables (E&L) is a specialization within pharmaceutical development that studies...
Improve Chromatographic Separations: Consider Mobile Phase pH & Analyte pKa
Chromatography aims to separate an analyte mixture into sharp, symmetrical, and well-resolved peaks for quantitative and qualitative analysis. To do this, it is crucial to understand ionization and the ionic form(s) of analytes at a given pH. The use of predictive software tools allows quick selection of optimal conditions and helps build robustness into methods from the start.