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ACDLabs
How evolving analytical and automation tools are positively impacting forced degradation studies in pharmaceutical development The goal of stress testing or forced degradation in pharmaceutical development is to comprehensively compile relevant degradation pathways, such that all degradation products are formed at detectable levels. This field has grown significantly in the past 20 years, fueled in...

ACDLabs
Efficient design, planning, execution, and analysis of catalyst screening experiments can present a significant productivity challenge to process chemistry groups. Katalyst D2D provides scientists with a single application interface to effectively identify catalytic conditions for process routes of interest as efficiently as possible.

Sherry Myles
New software facilitates the design, planning, execution and analysis of high throughput experiments to optimize the efficiency of product development—from Design to Decide Toronto, Canada (March 19, 2019)—ACD/Labs, an informatics company that is celebrating 25 years of providing analytical and chemical knowledge management solutions for R&D, today announced the launch of a new web-based application...

ACDLabs
Untargeted analysis of a composite house dust sample has been performed as part of a collaborative effort to evaluate the progress in the field of suspect and nontarget screening and build an extensive database of organic indoor environment contaminants. It was concluded that the use of multiple analytical techniques was required for a comprehensive characterization...

ACDLabs
This article describes a simple approach for the development and implementation of an efficient ultra-high performance liquid chromatography (UHPLC) assay that is extensively applied to the separation and analysis of multicomponent reaction mixtures of closely related pharmaceutical intermediates and impurities. ACD/LC Simulator was used in conjunction with multi-column and multi-solvent UHPLC screening to optimize methods.

ACDLabs
Robert Roe looks at regulatory and technological changes that are changing the way drug development is carried out. “One thing that Anderson says could be very useful in overcoming the challenges in maintaining control of data in the face of an increasingly outsourced business model, is data exchange. ‘Data access points can be limited, just...

ACDLabs
The ability to quickly and reliably separate and identify active components in natural product mixtures “using bio-assay and/or mass spectrometry guided fractionation” is critical for successful natural product-based drug discovery. Dereplication is the practice of screening active compounds early in the development process, to recognize and eliminate compounds that have been previously studied. This enables...