Forced Degradation Data Management in Drug Development
This application note explores how you can increase your team’s efficiency and simplify collaboration during forced degradation research with Luminata.
Eyes on Lipinski’s Rule of Five: A New “Rule of Thumb” for Physicochemical Design Space of Ophthalmic Drugs
The study objective was to investigate molecular thermodynamic properties of approved ophthalmic drugs and derive a framework outlining physicochemical design space for product development. Software on the Percepta Platform were used to predict the physicochemical properties of these ophthalmic drugs.
Computational Estimation of the Acidities of Pyrimidines and Related Compounds
This article highlights the use of ACD/pKa to obtain computed pKa values for the pyrimidines and related heterocycles in this QSAR study; and also tests the software’s ability to estimate pKas for these compounds.
Modifying current thin-film microextraction (TFME) solutions for analyzing prohibited substances: Evaluating new coatings using liquid chromatography
For identifying and quantifying prohibited substances, solid-phase microextraction (SPME) continues to arouse interest as a sample preparation method. However, the practical implementation of this method in routine laboratory testing is currently hindered by the limited number of coatings compatible with the ubiquitous high-performance liquid chromatography (HPLC) systems. This evaluation enables selection of the best-performing coatings...
Pandemic leads to challenges, opportunities in drug development
Joe DiMartino of ACD/Labs discusses the obstacles faced by drug development professionals in recent months, and ways they rose to the occasion.
The Analytical Scientist Innovation Awards 2021
After open nominations and scrutiny from our expert judging panel, the Analytical Scientist showcases 15 trailblazing technologies (including Spectrus JS) that cut the mustard in this year’s TASIAs.
Trends in Lab Automation
Richard Lee explains how artificial intelligence/machine learning and automation are not dependent on each other, and the benefits of storing data in the cloud.
Appraisal of breast cancer drugs and their precursors by Signal Amplification By Reversible Exchange
The purpose of this study was to develop the application method of Signal Amplification By Reversible Exchange (SABRE) hyperpolarization to a pharmaceutically approved drug Letrozole.
Reaching New Heights with High Throughput Experimentation
Reaching New Heights with High Throughput Experimentation High throughput experimentation is back again. It’s actually been with us for decades, but companies are paying more attention to this powerful approach to chemistry. They’ve solved some old problems, gained a better understanding of how to design HTE studies, and realized the data-science potential unlocked by high...